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Accurate detection and quantification of epigenetic and genetic second hits in BRCA1 and BRCA2-associated hereditary breast and ovarian cancer reveals multiple co-acting second hits.
Van Heetvelde, Mattias; Van Bockstal, Mieke; Poppe, Bruce; Lambein, Kathleen; Rosseel, Toon; Atanesyan, Lilit; Deforce, Dieter; Van Den Berghe, Ivo; De Leeneer, Kim; Van Dorpe, Jo; Vral, Anne; Claes, Kathleen B M.
Afiliação
  • Van Heetvelde M; Center for Medical Genetics Ghent, Ghent University Hospital, Medical Research Building 1, Corneel Heymanslaan 10, B-9000, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), B-9000, Ghent, Belgium; Department of Basic Medical Sciences, Ghent University, Entrance 46, De Pintelaan 185, B-9000, Gh
  • Van Bockstal M; Department of Pathology, Ghent University Hospital, Entrance 23, Corneel Heymanslaan 10, B-9000, Ghent, Belgium. Electronic address: mieke.vanbockstal@ugent.be.
  • Poppe B; Center for Medical Genetics Ghent, Ghent University Hospital, Medical Research Building 1, Corneel Heymanslaan 10, B-9000, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), B-9000, Ghent, Belgium. Electronic address: bruce.poppe@ugent.be.
  • Lambein K; Department of Pathology, AZ St Lucas Hospital, Groenebriel 1, B-9000, Ghent, Belgium; Department of Oncology, KU Leuven, Surgical Oncology, University Hospital Leuven Gasthuisberg, Herestraat 49, O&N1 Box 818, B-3000, Leuven, Belgium. Electronic address: kathleen.lambein@azstlucas.be.
  • Rosseel T; Center for Medical Genetics Ghent, Ghent University Hospital, Medical Research Building 1, Corneel Heymanslaan 10, B-9000, Ghent, Belgium. Electronic address: toon.rosseel@ugent.be.
  • Atanesyan L; MRC-Holland, Willem Schoutenstraat 1, 1057 DL, Amsterdam, The Netherlands. Electronic address: l.atanesyan@mlpa.com.
  • Deforce D; Cancer Research Institute Ghent (CRIG), B-9000, Ghent, Belgium; Faculty of Pharmaceutical Sciences, Laboratory of Pharmaceutical Biotechnology, Ghent University, Ottergemsesteenweg 460, B-9000, Ghent, Belgium. Electronic address: dieter.deforce@ugent.be.
  • Van Den Berghe I; Department of Pathology, AZ Sint Jan Hospital Brugge-Oostend, Ruddershove 10, B-8000, Brugge, Belgium. Electronic address: anatomopathologie.brugge@azsintjan.be.
  • De Leeneer K; Center for Medical Genetics Ghent, Ghent University Hospital, Medical Research Building 1, Corneel Heymanslaan 10, B-9000, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), B-9000, Ghent, Belgium. Electronic address: kim.deleeneer@ugent.be.
  • Van Dorpe J; Cancer Research Institute Ghent (CRIG), B-9000, Ghent, Belgium; Department of Pathology, Ghent University Hospital, Entrance 23, Corneel Heymanslaan 10, B-9000, Ghent, Belgium. Electronic address: jo.vandorpe@ugent.be.
  • Vral A; Cancer Research Institute Ghent (CRIG), B-9000, Ghent, Belgium; Department of Basic Medical Sciences, Ghent University, Entrance 46, De Pintelaan 185, B-9000, Ghent, Belgium. Electronic address: anne.vral@ugent.be.
  • Claes KBM; Center for Medical Genetics Ghent, Ghent University Hospital, Medical Research Building 1, Corneel Heymanslaan 10, B-9000, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), B-9000, Ghent, Belgium. Electronic address: kathleen.claes@ugent.be.
Cancer Lett ; 425: 125-133, 2018 07 01.
Article em En | MEDLINE | ID: mdl-29580810
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Análise de Sequência de DNA / Proteína BRCA1 / Proteína BRCA2 / Síndrome Hereditária de Câncer de Mama e Ovário Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: Cancer Lett Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Gana
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Análise de Sequência de DNA / Proteína BRCA1 / Proteína BRCA2 / Síndrome Hereditária de Câncer de Mama e Ovário Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: Cancer Lett Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Gana