The Neurotoxic Role of Extracellular Tau Protein.
Int J Mol Sci
; 19(4)2018 Mar 27.
Article
em En
| MEDLINE
| ID: mdl-29584657
ABSTRACT
Tauopathies are a class of neurodegenerative diseases associated with the microtubule-associated protein tau, with Alzheimer's disease (AD) being the most prevalent related disorder. Neurofibrillary tangles (NFTs) are one of the neuropathological hallmarks present in the brains of AD patients. Because NFTs are aberrant intracellular inclusions formed by hyperphosphorylated tau, it was initially proposed that phosphorylated and/or aggregated intracellular tau protein was causative of neuronal death. However, recent studies suggest a toxic role for non-phosphorylated and non-aggregated tau when it is located in the brain extracellular space. In this work, we will discuss the neurotoxic role of extracellular tau as well its involvement in the spreading of tau pathologies.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Emaranhados Neurofibrilares
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Proteínas tau
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Doença de Alzheimer
Limite:
Humans
Idioma:
En
Revista:
Int J Mol Sci
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Espanha