Synthesis, biological evaluation, and docking studies of novel 5,6-diaryl-1,2,4-triazine thiazole derivatives as a new class of &#945;-glucosidase inhibitors.

Wang, Guangcheng; Peng, Zhiyun; Gong, Zipeng; Li, Yongjun

Synthesis, biological evaluation, and docking studies of novel 5,6-diaryl-1,2,4-triazine thiazole derivatives as a new class of α-glucosidase inhibitors.

Wang, Guangcheng; Peng, Zhiyun; Gong, Zipeng; Li, Yongjun.

Afiliação

Wang G; Guizhou Provincial Key Laboratory of Pharmaceutics, State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550004, China; Guizhou Provincial Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, Guizhou Medica
Peng Z; Guizhou Provincial Key Laboratory of Pharmaceutics, State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550004, China; Guizhou Provincial Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, Guizhou Medica
Gong Z; Guizhou Provincial Key Laboratory of Pharmaceutics, State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550004, China; School of Pharmacy, Guizhou Medical University, Guiyang 550004, China.
Li Y; Guizhou Provincial Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, Guizhou Medical University, Guiyang 550004, China; School of Pharmacy, Guizhou Medical University, Guiyang 550004, China. Electronic address: liyongjun_gmu@163.com.

Bioorg Chem ; 78: 195-200, 2018 08.

Article em En | MEDLINE | ID: mdl-29587132

Assuntos

Inibidores de Glicosídeo Hidrolases/farmacologia; Simulação de Acoplamento Molecular; Tiazóis/farmacologia; Triazinas/farmacologia; alfa-Glucosidases/metabolismo; Relação Dose-Resposta a Droga; Inibidores de Glicosídeo Hidrolases/síntese química; Inibidores de Glicosídeo Hidrolases/química; Humanos; Estrutura Molecular; Relação Estrutura-Atividade; Tiazóis/química; Triazinas/síntese química; Triazinas/química

Palavras-chave

Molecular docking; Thiazole; Triazine; α-Glucosidase

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiazóis / Triazinas / Alfa-Glucosidases / Simulação de Acoplamento Molecular / Inibidores de Glicosídeo Hidrolases Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2018 Tipo de documento: Article

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