Evidence and Function Relevance of Native DOR-MOR Heteromers.
Handb Exp Pharmacol
; 247: 115-127, 2018.
Article
em En
| MEDLINE
| ID: mdl-29633181
ABSTRACT
Opioid receptors are the sites of action for morphine and most other clinically used opioid drugs. Abundant evidence now demonstrates that different opioid receptor types can physically associate to form heteromers. Owing to their constituent monomers' involvement in analgesia, mu/delta opioid receptor (M/DOR) heteromers have been a particular focus of attention. Understandings of the physiological relevance and indisputable proof of M/DOR formation in vivo are still evolving. This aspect of the field has been slow to progress in large part by the limitations of most available experimental models; recently however, promising progress is being made. As a result, the long-repeated promise of opioid receptor heteromers as selective therapeutic targets is now being realized.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores Opioides delta
/
Receptores Opioides mu
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Handb Exp Pharmacol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos