The <sub>95</sub>RGD<sub>97</sub> sequence on the A&#945; chain of fibrinogen is essential for binding to its erythrocyte receptor.

Carvalho, Filomena A; Guedes, Ana Filipa; Duval, Cedric; Macrae, Fraser L; Swithenbank, Luke; Farrell, David H; Ariëns, Robert As; Santos, Nuno C

The ₉₅RGD₉₇ sequence on the Aα chain of fibrinogen is essential for binding to its erythrocyte receptor.

Carvalho, Filomena A; Guedes, Ana Filipa; Duval, Cedric; Macrae, Fraser L; Swithenbank, Luke; Farrell, David H; Ariëns, Robert As; Santos, Nuno C.

Afiliação

Carvalho FA; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Guedes AF; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Duval C; Theme Thrombosis, Division of Cardiovascular and Diabetes Research, Leeds Institute for Genetics, Health and Therapeutics, University of Leeds, Leeds, UK.
Macrae FL; Theme Thrombosis, Division of Cardiovascular and Diabetes Research, Leeds Institute for Genetics, Health and Therapeutics, University of Leeds, Leeds, UK.
Swithenbank L; Theme Thrombosis, Division of Cardiovascular and Diabetes Research, Leeds Institute for Genetics, Health and Therapeutics, University of Leeds, Leeds, UK.
Farrell DH; Department of Surgery, Oregon Health and Science University, Portland, OR, USA.
Ariëns RA; Theme Thrombosis, Division of Cardiovascular and Diabetes Research, Leeds Institute for Genetics, Health and Therapeutics, University of Leeds, Leeds, UK.
Santos NC; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.

Int J Nanomedicine ; 13: 1985-1992, 2018.

Article em En | MEDLINE | ID: mdl-29662311

Assuntos

Eritrócitos/metabolismo; Fibrinogênio/metabolismo; Receptores de Fibrinogênio/metabolismo; Sítios de Ligação; Fibrina/metabolismo; Fibrinogênio/genética; Humanos; Integrinas/metabolismo; Microscopia de Força Atômica; Mutação; Ligação Proteica; Trombose/metabolismo

Palavras-chave

atomic force microscopy; erythrocyte aggregation; fibrin clot; fibrinogen; mutant protein

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrinogênio / Receptores de Fibrinogênio / Eritrócitos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Int J Nanomedicine Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Portugal

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google