Syntheses and structure-activity relationships on antibacterial and anti-ulcerative colitis properties of quaternary 13-substituted palmatines and 8-oxo-13-substituted dihydropalmatines.

Song, Li; Zhang, Hai-Jing; Deng, An-Jun; Li, Jia; Li, Xiang; Li, Zhi-Hong; Zhang, Zhi-Hui; Wu, Lian-Qiu; Wang, Sheng-Qi; Qin, Hai-Lin

Song, Li; Zhang, Hai-Jing; Deng, An-Jun; Li, Jia; Li, Xiang; Li, Zhi-Hong; Zhang, Zhi-Hui; Wu, Lian-Qiu; Wang, Sheng-Qi; Qin, Hai-Lin.

Afiliação

Song L; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Zhang HJ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Deng AJ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Li J; Beijing Institute of Radiation Medicine, Beijing 100850, China.
Li X; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Li ZH; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Zhang ZH; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Wu LQ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: wlq@imm.ac.cn.
Wang SQ; Beijing Institute of Radiation Medicine, Beijing 100850, China. Electronic address: sqwang@bmi.ac.cn.
Qin HL; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: qinhailin@imm.ac.cn.

Bioorg Med Chem ; 26(9): 2586-2598, 2018 05 15.

Article em En | MEDLINE | ID: mdl-29680749

Assuntos

Antibacterianos/farmacologia; Antiulcerosos/farmacologia; Alcaloides de Berberina/farmacologia; Animais; Antibacterianos/síntese química; Antibacterianos/química; Antibacterianos/uso terapêutico; Antiulcerosos/síntese química; Antiulcerosos/química; Antiulcerosos/uso terapêutico; Alcaloides de Berberina/síntese química; Alcaloides de Berberina/química; Alcaloides de Berberina/uso terapêutico; Peso Corporal/efeitos dos fármacos; Candida albicans/efeitos dos fármacos; Colite Ulcerativa/tratamento farmacológico; Colo/metabolismo; Escherichia coli/efeitos dos fármacos; Levofloxacino/farmacologia; Camundongos Endogâmicos C57BL; Testes de Sensibilidade Microbiana; Estrutura Molecular; Contração Muscular/efeitos dos fármacos; Staphylococcus aureus/efeitos dos fármacos; Relação Estrutura-Atividade; Sulfassalazina/farmacologia; Proteína 1 de Ligação a X-Box/metabolismo

Palavras-chave

Anti-ulcerative colitis; Antibacteria; Quaternary palmatine; Structure modification; Structure-activity relationships

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Alcaloides de Berberina / Antiulcerosos / Antibacterianos Limite: Animals Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

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