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CRISPR genetic screens to discover host-virus interactions.
McDougall, William M; Perreira, Jill M; Reynolds, Erin C; Brass, Abraham L.
Afiliação
  • McDougall WM; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA.
  • Perreira JM; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA.
  • Reynolds EC; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA.
  • Brass AL; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA; Gastroenterology Division, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA. Electronic address: abraham.brass@umassmed.edu.
Curr Opin Virol ; 29: 87-100, 2018 04.
Article em En | MEDLINE | ID: mdl-29684735
ABSTRACT
Viruses impose an immense burden on human health. With the goal of treating and preventing viral infections, researchers have carried out genetic screens to improve our understanding of viral dependencies and identify potential anti-viral strategies. The emergence of CRISPR genetic screening tools has facilitated this effort by enabling host-virus screens to be undertaken in a more versatile and fidelitous manner than previously possible. Here we review the growing number of CRISPR screens which continue to increase our understanding of host-virus interactions.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus / Viroses / Testes Genéticos / Interações Hospedeiro-Patógeno / Sistemas CRISPR-Cas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Curr Opin Virol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus / Viroses / Testes Genéticos / Interações Hospedeiro-Patógeno / Sistemas CRISPR-Cas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Curr Opin Virol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos