[Effect of rhEGF on the levels of serum EGF and inflammatory cytokines in patients with oral and maxillofacial trauma].

ABSTRACT

PURPOSE: To investigate the effect of debridement combined with recombinant human epidermal growth factor (rhEGF) on wound healing, scar formation, serum epidermal growth factor and inflammatory factors in patients with oral and maxillofacial trauma. METHODS: Eight-two cases with oral and maxillofacial trauma treated in our hospital (January 2015 to December 2016) were retrospectively analyzed. All patients received routine treatment, 41 received rhEGF besides routine treatment (experimental group), 41 patients received only cosmetic debridement and suturing (control group). The effect, wound healing time of 2 groups were recorded and compared. The serum epidermal growth factor, interleukin -6 (IL-6), tumor necrosis factor alpha (TNF-α) and interleukin -1 (Interleukin-1, IL-1) before and after operation were compared between 2 groups. SPSS16.0 software package was used to analyze the data. RESULTS: The average wound healing time of the patients in the experimental group was 5.1±1.3 days, and the average wound healing time of patients in the control group was 7.4±1.9 days, the difference between 2 groups was statistically significant (t=6.397, P<0.01). The effective rate of the experimental group was significantly higher than the control group (P<0.05). Before operation, the serum epidermal growth factor, IL-6, TNF-α and IL-1 in 2 groups had no significant differences (P>0.05); 2 days and 5 days after operation, the serum epidermal growth factor level of the experimental group was significantly higher than the control group(P<0.05). The serum IL-6, TNF-α, IL-1 level of the experimental group were significantly lower than the control group(P<0.05).The side effects happened in the experimental group were significantly lower than control group (P<0.05). CONCLUSIONS: Patients with oral and maxillofacial trauma treated by debridement combined with rhEGF can promote wound healing and reduce the degree of inflammation.