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Cardiovascular abnormalities in patients with oral cleft: a clinical-electrocardiographic-echocardiographic study.
Leite, Gisele C P; Ururahy, Marcela A G; Bezerra, João F; Lima, Valéria M G D M; Costa, Maria I F; Freire, Sandra S C; Luchessi, André D; Maia, Jussara M C; Brito, Maria E F; Gil-da-Silva-Lopes, Vera L; Rezende, Adriana A.
Afiliação
  • Leite GCP; Departamento de Pediatria, Universidade Federal do Rio Grande do Norte, Natal, RN, BR.
  • Ururahy MAG; Departamento de Analises Clinicas e Toxicologicas, Universidade Federal do Rio Grande do Norte, Natal, RN, BR.
  • Bezerra JF; Departamento de Analises Clinicas e Toxicologicas, Universidade Federal do Rio Grande do Norte, Natal, RN, BR.
  • Lima VMGDM; Departamento de Analises Clinicas e Toxicologicas, Universidade Federal do Rio Grande do Norte, Natal, RN, BR.
  • Costa MIF; Departamento de Pediatria, Universidade Federal do Rio Grande do Norte, Natal, RN, BR.
  • Freire SSC; Departamento de Pediatria, Universidade Federal do Rio Grande do Norte, Natal, RN, BR.
  • Luchessi AD; Departamento de Analises Clinicas e Toxicologicas, Universidade Federal do Rio Grande do Norte, Natal, RN, BR.
  • Maia JMC; Departamento de Pediatria, Universidade Federal do Rio Grande do Norte, Natal, RN, BR.
  • Brito MEF; Departamento de Pediatria, Universidade Federal do Rio Grande do Norte, Natal, RN, BR.
  • Gil-da-Silva-Lopes VL; Departamento de Genetica Medica, Universidade Estadual de Campinas, Campinas, SP, BR.
  • Rezende AA; Departamento de Analises Clinicas e Toxicologicas, Universidade Federal do Rio Grande do Norte, Natal, RN, BR.
Clinics (Sao Paulo) ; 73: e108, 2018.
Article em En | MEDLINE | ID: mdl-29694606
ABSTRACT

OBJECTIVES:

The present study aims to describe the clinical, electrocardiographic, and echocardiographic cardiological findings in a group of patients with oral clefts.

METHODS:

This is a prospective cross-sectional study on 70 children (age range from 13 days to 19 years) with oral clefts who attended the multidisciplinary program of a university hospital from March 2013 to September 2014. The patients were evaluated by a pediatric cardiologist and underwent detailed anamnesis, physical examination, electrocardiogram, and echocardiogram.

RESULTS:

Sixty percent of the patients were male; 55.7% presented with cleft lip and palate, and 40.0% presented with health complaints. Comorbidities were found in 44.3%. Relevant pregnancy, neonatal, family and personal antecedents were present in 55.7%, 27.1%, 67.2%, and 24.3% of the patients, respectively. Regarding the antecedents, 15.2% of the patients presented with a cardiac murmur, 49.0% with a familial risk of developing plurimetabolic syndrome, and 6% with family antecedents of rheumatic fever. Electrocardiographic evaluation showed one case of atrioventricular block. Echocardiograms were abnormal in 35.7% of the exams, including 5 cases of mitral valve prolapse - one of which was diagnosed with rheumatic heart disease.

CONCLUSION:

The finding of a family risk of developing plurimetabolic syndrome and a diagnosis of rheumatic heart disease indicates that patients with oral clefts may be more prone to developing acquired heart disease. Thus, our findings highlight the importance of anamnesis and methodological triangulation (clinical-electrocardiographic-echocardiographic) in the investigation of patients with oral clefts and emphasize that cardiological follow-up to evaluate acquired and/or rhythm heart diseases is necessary. This strategy permits comorbidity prevention and individualized planned treatment.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenda Labial / Fissura Palatina / Anormalidades Cardiovasculares Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: Clinics (Sao Paulo) Assunto da revista: MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenda Labial / Fissura Palatina / Anormalidades Cardiovasculares Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: Clinics (Sao Paulo) Assunto da revista: MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil