Association of Lonafarnib Treatment vs No Treatment With Mortality Rate in Patients With Hutchinson-Gilford Progeria Syndrome.

Gordon, Leslie B; Shappell, Heather; Massaro, Joe; D'Agostino, Ralph B; Brazier, Joan; Campbell, Susan E; Kleinman, Monica E; Kieran, Mark W

Gordon, Leslie B; Shappell, Heather; Massaro, Joe; D'Agostino, Ralph B; Brazier, Joan; Campbell, Susan E; Kleinman, Monica E; Kieran, Mark W.

Afiliação

Gordon LB; Department of Pediatrics, Division of Genetics, Hasbro Children's Hospital, Providence, Rhode Island.
Shappell H; Warren Alpert Medical School of Brown University, Providence, Rhode Island.
Massaro J; Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
D'Agostino RB; Department of Mathematics and Statistics, Boston University, Harvard Clinical Research Institute, Boston, Massachusetts.
Brazier J; Department of Mathematics and Statistics, Boston University, Harvard Clinical Research Institute, Boston, Massachusetts.
Campbell SE; Department of Mathematics and Statistics, Boston University, Harvard Clinical Research Institute, Boston, Massachusetts.
Kleinman ME; Center for Gerontology and Health Care Research, Brown University, Providence, Rhode Island.
Kieran MW; Center for Gerontology and Health Care Research, Brown University, Providence, Rhode Island.

JAMA ; 319(16): 1687-1695, 2018 04 24.

Article em En | MEDLINE | ID: mdl-29710166

Assuntos

Inibidores Enzimáticos/uso terapêutico; Fosfotransferases (Aceptor do Grupo Fosfato)/antagonistas & inibidores; Piperidinas/uso terapêutico; Progéria/tratamento farmacológico; Piridinas/uso terapêutico; Adolescente; Adulto; Causas de Morte; Criança; Estudos de Coortes; Feminino; Humanos; Estimativa de Kaplan-Meier; Lamina Tipo A/biossíntese; Lamina Tipo A/metabolismo; Masculino; Progéria/genética; Progéria/mortalidade; Processamento de Proteína Pós-Traducional; Adulto Jovem

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Progéria / Piridinas / Fosfotransferases (Aceptor do Grupo Fosfato) / Inibidores Enzimáticos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: JAMA Ano de publicação: 2018 Tipo de documento: Article

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