From Split-Pool Libraries to Spatially Addressable Microarrays and Its Application to Functional Proteomic Profiling.

Small molecules encoded with peptidonucleic acid (PNA) were used to probe protein function in a microarray format. The PNA tag served to encode the synthetic history of the small molecule and to positionally encode the identity of the small molecule by its location upon hybridization to an oligonucleotide microarray.