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Cholesterol and fatty acids grease the wheels of Mycobacterium tuberculosis pathogenesis.
Wilburn, Kaley M; Fieweger, Rachael A; VanderVen, Brian C.
Afiliação
  • Wilburn KM; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14850, USA.
  • Fieweger RA; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14850, USA.
  • VanderVen BC; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14850, USA.
Pathog Dis ; 76(2)2018 03 01.
Article em En | MEDLINE | ID: mdl-29718271
Tuberculosis is a distinctive disease in which the causative agent, Mycobacterium tuberculosis, can persist in humans for decades by avoiding clearance from host immunity. During infection, M. tuberculosis maintains viability by extracting and utilizing essential nutrients from the host, and this is a prerequisite for all of the pathogenic activities that are deployed by the bacterium. In particular, M. tuberculosis preferentially acquires and metabolizes host-derived lipids (fatty acids and cholesterol), and the bacterium utilizes these substrates to cause and maintain disease. In this review, we discuss our current understanding of lipid utilization by M. tuberculosis, and we describe how these pathways promote pathogenesis to fuel metabolic processes in the bacillus. Finally, we highlight weaknesses in these pathways that potentially can be targeted for drug discovery.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose / Colesterol / Ácidos Graxos / Mycobacterium tuberculosis Tipo de estudo: Etiology_studies Limite: Animals / Humans Idioma: En Revista: Pathog Dis Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose / Colesterol / Ácidos Graxos / Mycobacterium tuberculosis Tipo de estudo: Etiology_studies Limite: Animals / Humans Idioma: En Revista: Pathog Dis Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos