Subthalamic nucleus deep brain stimulation evokes resonant neural activity.
Ann Neurol
; 83(5): 1027-1031, 2018 05.
Article
em En
| MEDLINE
| ID: mdl-29727475
ABSTRACT
Deep brain stimulation (DBS) is a rapidly expanding treatment for neurological and psychiatric conditions; however, a target-specific biomarker is required to optimize therapy. Here, we show that DBS evokes a large-amplitude resonant neural response focally in the subthalamic nucleus. This response is greatest in the dorsal region (the clinically optimal stimulation target for Parkinson disease), coincides with improved clinical performance, is chronically recordable, and is present under general anesthesia. These features make it a readily utilizable electrophysiological signal that could potentially be used for guiding electrode implantation surgery and tailoring DBS therapy to improve patient outcomes. Ann Neurol 2018;831027-1031.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
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Resultado do Tratamento
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Núcleo Subtalâmico
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Estimulação Encefálica Profunda
Limite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Ann Neurol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Austrália