Lanostane triterpenoids from Tricholoma pardinum with NO production inhibitory and cytotoxic activities.
Phytochemistry
; 152: 105-112, 2018 Aug.
Article
em En
| MEDLINE
| ID: mdl-29758519
ABSTRACT
Eight undescribed lanostane triterpenoids, pardinols AâH, along with one previously reported lanostane triterpenoid, namely saponaceol B, were isolated from the fruiting bodies of Tricholoma pardinum. Their structures and stereoconfigurations were established via combination of extensive spectroscopic analyses, alkaline methanolysis method and TDDFT/ECD calculations. Pardinols B and E-H exhibited certain inhibition activities of nitric oxide (NO) production with IC50 value ranging from 5.3 to 14.7⯵M, as well as cytotoxicities against human cancer cell-lines.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Triterpenos
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Carpóforos
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Tricholoma
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Macrófagos
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Antineoplásicos
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Óxido Nítrico
Limite:
Animals
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Humans
Idioma:
En
Revista:
Phytochemistry
Ano de publicação:
2018
Tipo de documento:
Article