SURF4 has oncogenic potential in NIH3T3 cells.
Biochem Biophys Res Commun
; 502(1): 43-47, 2018 07 07.
Article
em En
| MEDLINE
| ID: mdl-29777698
ABSTRACT
SURF4, which is located in the Surfeit gene cluster, encodes for a conserved integral membrane protein containing multiple putative transmembrane regions. However, the physiological role of SURF4 has not been determined. We found that SURF4 demonstrated aberrant amplification and increased expression in the tumor tissues of several human cancer patients. Overexpression of SURF4 led to increased cell proliferation, migration, and maintenance of anchorage-independent growth. In addition, NIH3T3 cells overexpressing SURF4 induced tumor growth in the mice. Collectively, our findings demonstrate that SURF4 has the potential for inducing cellular transformation and cell migration in vitro and has oncogenic transformation ability in vivo.
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MEDLINE
Assunto principal:
Regulação Neoplásica da Expressão Gênica
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Regulação para Cima
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Transformação Celular Neoplásica
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Carcinogênese
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Proteínas de Membrana
Limite:
Animals
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Humans
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
2018
Tipo de documento:
Article