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Perivascular Adipose Tissue-Derived PDGF-D Contributes to Aortic Aneurysm Formation During Obesity.
Zhang, Ze-Bei; Ruan, Cheng-Chao; Lin, Jing-Rong; Xu, Lian; Chen, Xiao-Hui; Du, Ya-Nan; Fu, Meng-Xia; Kong, Ling-Ran; Zhu, Ding-Liang; Gao, Ping-Jin.
Afiliação
  • Zhang ZB; The State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Department of Hypertension, Ruijin Hospital and Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
  • Ruan CC; The State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Department of Hypertension, Ruijin Hospital and Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China gaopingjin@sibs.ac.cn ccruan@sibs.ac.cn.
  • Lin JR; The State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Department of Hypertension, Ruijin Hospital and Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
  • Xu L; The State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Department of Hypertension, Ruijin Hospital and Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
  • Chen XH; The State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Department of Hypertension, Ruijin Hospital and Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
  • Du YN; The State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Department of Hypertension, Ruijin Hospital and Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
  • Fu MX; The State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Department of Hypertension, Ruijin Hospital and Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
  • Kong LR; The State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Department of Hypertension, Ruijin Hospital and Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
  • Zhu DL; The State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Department of Hypertension, Ruijin Hospital and Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
  • Gao PJ; The State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Department of Hypertension, Ruijin Hospital and Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China gaopingjin@sibs.ac.cn ccruan@sibs.ac.cn.
Diabetes ; 67(8): 1549-1560, 2018 08.
Article em En | MEDLINE | ID: mdl-29794241
Assuntos
Aorta Abdominal/metabolismo; Aneurisma da Aorta Abdominal/etiologia; Gordura Intra-Abdominal/metabolismo; Linfocinas/metabolismo; Obesidade/fisiopatologia; Fator de Crescimento Derivado de Plaquetas/metabolismo; Túnica Adventícia/efeitos dos fármacos; Túnica Adventícia/imunologia; Túnica Adventícia/metabolismo; Túnica Adventícia/patologia; Angiotensina II/administração & dosagem; Angiotensina II/efeitos adversos; Animais; Aorta Abdominal/diagnóstico por imagem; Aorta Abdominal/efeitos dos fármacos; Aorta Abdominal/patologia; Aneurisma da Aorta Abdominal/diagnóstico por imagem; Aneurisma da Aorta Abdominal/metabolismo; Aneurisma da Aorta Abdominal/patologia; Benzimidazóis/farmacologia; Células Cultivadas; Dieta Hiperlipídica/efeitos adversos; Implantes de Medicamento; Regulação da Expressão Gênica/efeitos dos fármacos; Mediadores da Inflamação/metabolismo; Gordura Intra-Abdominal/efeitos dos fármacos; Gordura Intra-Abdominal/imunologia; Gordura Intra-Abdominal/patologia; Linfocinas/agonistas; Linfocinas/antagonistas & inibidores; Linfocinas/genética; Masculino; Camundongos; Camundongos Mutantes; Camundongos Transgênicos; Obesidade/etiologia; Obesidade/metabolismo; Obesidade/patologia; Especificidade de Órgãos; Fator de Crescimento Derivado de Plaquetas/agonistas; Fator de Crescimento Derivado de Plaquetas/antagonistas & inibidores; Fator de Crescimento Derivado de Plaquetas/genética; Quinolinas/farmacologia; Proteínas Recombinantes/química; Proteínas Recombinantes/metabolismo; Gordura Subcutânea Abdominal/efeitos dos fármacos; Gordura Subcutânea Abdominal/imunologia; Gordura Subcutânea Abdominal/metabolismo; Gordura Subcutânea Abdominal/patologia; Análise de Sobrevida
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aorta Abdominal / Fator de Crescimento Derivado de Plaquetas / Linfocinas / Aneurisma da Aorta Abdominal / Gordura Intra-Abdominal / Obesidade Tipo de estudo: Etiology_studies Idioma: En Revista: Diabetes Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aorta Abdominal / Fator de Crescimento Derivado de Plaquetas / Linfocinas / Aneurisma da Aorta Abdominal / Gordura Intra-Abdominal / Obesidade Tipo de estudo: Etiology_studies Idioma: En Revista: Diabetes Ano de publicação: 2018 Tipo de documento: Article