Adaptive genome duplication affects patterns of molecular evolution in Saccharomyces cerevisiae.
PLoS Genet
; 14(5): e1007396, 2018 05.
Article
em En
| MEDLINE
| ID: mdl-29799840
ABSTRACT
Genome duplications are important evolutionary events that impact the rate and spectrum of beneficial mutations and thus the rate of adaptation. Laboratory evolution experiments initiated with haploid Saccharomyces cerevisiae cultures repeatedly experience whole-genome duplication (WGD). We report recurrent genome duplication in 46 haploid yeast populations evolved for 4,000 generations. We find that WGD confers a fitness advantage, and this immediate fitness gain is accompanied by a shift in genomic and phenotypic evolution. The presence of ploidy-enriched targets of selection and structural variants reveals that autodiploids utilize adaptive paths inaccessible to haploids. We find that autodiploids accumulate recessive deleterious mutations, indicating an increased susceptibility for nonadaptive evolution. Finally, we report that WGD results in a reduced adaptation rate, indicating a trade-off between immediate fitness gains and long-term adaptability.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ploidias
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Saccharomyces cerevisiae
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Adaptação Fisiológica
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Genoma Fúngico
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Evolução Molecular
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Duplicação Gênica
Idioma:
En
Revista:
PLoS Genet
Assunto da revista:
GENETICA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos