How the definition of acceptable antigens and epitope analysis can facilitate transplantation of highly sensitized patients with excellent long-term graft survival.
Curr Opin Organ Transplant
; 23(4): 493-499, 2018 08.
Article
em En
| MEDLINE
| ID: mdl-29846197
ABSTRACT
PURPOSE OF REVIEW Highly sensitized patients awaiting a renal transplant have a low chance of receiving an organ offer. Defining acceptable antigens and using this information for allocation purposes can vastly enhance transplantation of this subgroup of patients, which is the essence of the Eurotransplant Acceptable Mismatch program. Acceptable antigens can be determined by extensive laboratory testing, as well as on basis of human leukocyte antigen (HLA) epitope analyses. RECENT FINDINGS:
Within the Acceptable Mismatch program, there is no effect of HLA mismatches on long-term graft survival. Furthermore, patients transplanted through the Acceptable Mismatch program have similar long-term graft survival to nonsensitized patients transplanted through regular allocation. Although HLA epitope analysis is already being used for defining acceptable HLA antigens for highly sensitized patients in the Acceptable Mismatch program, increasing knowledge on HLA antibody - epitope interactions will pave the way toward the definition of acceptable epitopes for highly sensitized patients in the future.SUMMARY:
Allocation based on acceptable antigens can facilitate transplantation of highly sensitized patients with excellent long-term graft survival.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Teste de Histocompatibilidade
/
Transplante de Rim
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Antígenos HLA
/
Epitopos
Limite:
Humans
Idioma:
En
Revista:
Curr Opin Organ Transplant
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Holanda