Induction of anaplastic lymphoma kinase (ALK) as a novel mechanism of EGFR inhibitor resistance in head and neck squamous cell carcinoma patient-derived models.

Ouyang, Xiaoming; Barling, Ashley; Lesch, Aletha; Tyner, Jeffrey W; Choonoo, Gabrielle; Zheng, Christina; Jeng, Sophia; West, Toni M; Clayburgh, Daniel; Courtneidge, Sara A; McWeeney, Shannon K; Kulesz-Martin, Molly

Ouyang, Xiaoming; Barling, Ashley; Lesch, Aletha; Tyner, Jeffrey W; Choonoo, Gabrielle; Zheng, Christina; Jeng, Sophia; West, Toni M; Clayburgh, Daniel; Courtneidge, Sara A; McWeeney, Shannon K; Kulesz-Martin, Molly.

Afiliação

Ouyang X; a Department of Dermatology , Oregon Health & Science University , 3181 SW Sam Jackson Park Rd., Portland , Oregon.
Barling A; b Department of Cell , Developmental & Cancer Biology, Oregon Health & Science University , 3181 SW Sam Jackson Park Rd., Portland , Oregon.
Lesch A; a Department of Dermatology , Oregon Health & Science University , 3181 SW Sam Jackson Park Rd., Portland , Oregon.
Tyner JW; a Department of Dermatology , Oregon Health & Science University , 3181 SW Sam Jackson Park Rd., Portland , Oregon.
Choonoo G; b Department of Cell , Developmental & Cancer Biology, Oregon Health & Science University , 3181 SW Sam Jackson Park Rd., Portland , Oregon.
Zheng C; c Division of Hematology and Medical Oncology , Oregon Health & Science University , 3181 SW Sam Jackson Park Rd., Portland , Oregon.
Jeng S; e Knight Cancer Institute, Oregon Health & Science University , 3181 SW Sam Jackson Park Rd., Portland , Oregon.
West TM; d Division of Bioinformatics and Computational Biology , Department of Medical Informatics & Clinical Epidemiology , Oregon Health & Science University , 3181 SW Sam Jackson Park Rd., Portland , Oregon.
Clayburgh D; d Division of Bioinformatics and Computational Biology , Department of Medical Informatics & Clinical Epidemiology , Oregon Health & Science University , 3181 SW Sam Jackson Park Rd., Portland , Oregon.
Courtneidge SA; d Division of Bioinformatics and Computational Biology , Department of Medical Informatics & Clinical Epidemiology , Oregon Health & Science University , 3181 SW Sam Jackson Park Rd., Portland , Oregon.
McWeeney SK; f Department of Pharmacology , University of California at Davis , 451 Health Science Dr., Davis , California.
Kulesz-Martin M; g Department of Otolaryngology-Head and Neck Surgery , Oregon Health & Science University , 3181 SW Sam Jackson Park Rd., Portland , Oregon.

Cancer Biol Ther ; 19(10): 921-933, 2018.

Article em En | MEDLINE | ID: mdl-29856687

Assuntos

Quinase do Linfoma Anaplásico/genética; Antineoplásicos/farmacologia; Resistencia a Medicamentos Antineoplásicos/genética; Receptores ErbB/antagonistas & inibidores; Inibidores de Proteínas Quinases/farmacologia; Carcinoma de Células Escamosas de Cabeça e Pescoço/genética; Quinase do Linfoma Anaplásico/metabolismo; Animais; Linhagem Celular Tumoral; Modelos Animais de Doenças; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Camundongos; Fosforilação; Interferência de RNA; RNA Interferente Pequeno/genética; Carcinoma de Células Escamosas de Cabeça e Pescoço/tratamento farmacológico; Carcinoma de Células Escamosas de Cabeça e Pescoço/metabolismo; Carcinoma de Células Escamosas de Cabeça e Pescoço/patologia; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

ALK; EGFR; EGFR inhibitor resistance; HNSCC; patient-derived models

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Resistencia a Medicamentos Antineoplásicos / Inibidores de Proteínas Quinases / Receptores ErbB / Carcinoma de Células Escamosas de Cabeça e Pescoço / Quinase do Linfoma Anaplásico / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cancer Biol Ther Assunto da revista: NEOPLASIAS / TERAPEUTICA Ano de publicação: 2018 Tipo de documento: Article

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