Cytochrome c takes on plasmalogen catabolism.
J Biol Chem
; 293(22): 8710-8711, 2018 06 01.
Article
em En
| MEDLINE
| ID: mdl-29858391
ABSTRACT
Plasmalogens-phospholipids containing a characteristic vinyl ether group-are precursors of lipids important for cellular signaling such as arachidonic acid. Plasmalogen catabolism involves cleavage of the vinyl ether bond, but the identity of the corresponding enzyme that cleaves the sn-1 vinyl ether bond was unknown. New research shows that cytochrome c, with some help from another lipid, catalyzes the oxidative cleavage of this bond. This discovery, and the subsequent mechanistic dissection, provides exciting new directions for lipid signaling research.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos de Vinila
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Plasmalogênios
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Estresse Oxidativo
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Citocromos c
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Hidrolases
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Mitocôndrias Cardíacas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Biol Chem
Ano de publicação:
2018
Tipo de documento:
Article