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Celastrol as a pentacyclic triterpenoid with chemopreventive properties.
Yadav, Priya; Jaswal, Vishal; Sharma, Ajay; Kashyap, Dharambir; Tuli, Hardeep S; Garg, Vivek K; Das, Shonkor K; Srinivas, R.
Afiliação
  • Yadav P; Department of Biotechnology, Maharishi Markandeshwar University, Mullana-Ambala, Haryana 133207, India.
  • Jaswal V; Department of Chemistry, Career Point University, Tikker-Kharwarian, Hamirpur, Himachal Pradesh 176041, India.
  • Sharma A; Department of Chemistry, Career Point University, Tikker-Kharwarian, Hamirpur, Himachal Pradesh 176041, India.
  • Kashyap D; Department of Histopathology, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, Punjab 160012, India.
  • Tuli HS; Department of Biotechnology, Maharishi Markandeshwar University, Mullana-Ambala, Haryana 133207, India.
  • Garg VK; Department of Biochemistry, Government Medical College & Hospital, Chandigarh, Punjab 160030, India.
  • Das SK; Bioresearch Laboratory, Department of Anatomy & Histology, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh.
  • Srinivas R; Walter Bushnell Bioscience Pvt Ltd, New Delhi 110017, India.
Pharm Pat Anal ; 7(4): 155-167, 2018 Jul.
Article em En | MEDLINE | ID: mdl-29882724
ABSTRACT
Celastrol is a highly investigated anticancer moiety. It is a pentacyclic triterpenoid, isolated several decades ago with promising role in chemoprevention. Celastrol has been found to target multiple proinflammatory, angiogenic and metastatic proteins. Inhibition of these targets results in significant reduction of cancer growth, survival and metastasis. This review summarizes the varied molecular targets of celastrol along with insight into the various recently published clinical, preclinical and industrial patents (2011-2017).
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Patentes como Assunto / Triterpenos / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Pharm Pat Anal Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Índia
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Patentes como Assunto / Triterpenos / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Pharm Pat Anal Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Índia