Chemical Elicitors of Antibiotic Biosynthesis in Actinomycetes.
Microorganisms
; 6(2)2018 06 08.
Article
em En
| MEDLINE
| ID: mdl-29890642
ABSTRACT
Whole genome sequencing of actinomycetes has uncovered a new immense realm of microbial chemistry and biology. Most biosynthetic gene clusters present in genomes were found to remain "silent" under standard cultivation conditions. Some small moleculeschemical elicitorscan be used to induce the biosynthesis of antibiotics in actinobacteria and to expand the chemical diversity of secondary metabolites. Here, we outline a brief account of the basic principles of the search for regulators of this type and their application.
Texto completo:
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Microorganisms
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Federação Russa