Systematic Mendelian randomization framework elucidates hundreds of CpG sites which may mediate the influence of genetic variants on disease.

Richardson, Tom G; Haycock, Philip C; Zheng, Jie; Timpson, Nicholas J; Gaunt, Tom R; Davey Smith, George; Relton, Caroline L; Hemani, Gibran

Richardson, Tom G; Haycock, Philip C; Zheng, Jie; Timpson, Nicholas J; Gaunt, Tom R; Davey Smith, George; Relton, Caroline L; Hemani, Gibran.

Afiliação

Richardson TG; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School (Population Health Sciences), University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK.
Haycock PC; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School (Population Health Sciences), University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK.
Zheng J; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School (Population Health Sciences), University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK.
Timpson NJ; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School (Population Health Sciences), University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK.
Gaunt TR; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School (Population Health Sciences), University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK.
Davey Smith G; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School (Population Health Sciences), University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK.
Relton CL; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School (Population Health Sciences), University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK.
Hemani G; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School (Population Health Sciences), University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK.

Hum Mol Genet ; 27(18): 3293-3304, 2018 09 15.

Article em En | MEDLINE | ID: mdl-29893838

Assuntos

Ilhas de CpG/ética; Metilação de DNA/genética; Doenças Genéticas Inatas/genética; Locos de Características Quantitativas/genética; Ilhas de CpG/genética; Variação Genética; Genoma Humano/genética; Humanos; Análise da Randomização Mendeliana

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ilhas de CpG / Metilação de DNA / Locos de Características Quantitativas / Doenças Genéticas Inatas Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Humans Idioma: En Revista: Hum Mol Genet Assunto da revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google