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Metabolic conversion of CI-1040 turns a cellular MEK-inhibitor into an antibacterial compound.
Bruchhagen, Christin; Jarick, Marcel; Mewis, Carolin; Hertlein, Tobias; Niemann, Silke; Ohlsen, Knut; Peters, Georg; Planz, Oliver; Ludwig, Stephan; Ehrhardt, Christina.
Afiliação
  • Bruchhagen C; Institute of Virology Muenster (IVM), Westfaelische Wilhelms-University Muenster, Von-Esmarch-Str. 56, D-48149, Muenster, Germany.
  • Jarick M; Institute for Molecular Infection Biology (IMIB), University of Wuerzburg, Josef-Schneider-Str. 2/D15, D-97080, Wuerzburg, Germany.
  • Mewis C; Institute of Virology Muenster (IVM), Westfaelische Wilhelms-University Muenster, Von-Esmarch-Str. 56, D-48149, Muenster, Germany.
  • Hertlein T; Institute for Molecular Infection Biology (IMIB), University of Wuerzburg, Josef-Schneider-Str. 2/D15, D-97080, Wuerzburg, Germany.
  • Niemann S; Institute of Medical Microbiology, University Hospital of Muenster, Domagkstr. 10, D-48149, Muenster, Germany.
  • Ohlsen K; Institute for Molecular Infection Biology (IMIB), University of Wuerzburg, Josef-Schneider-Str. 2/D15, D-97080, Wuerzburg, Germany.
  • Peters G; Institute of Medical Microbiology, University Hospital of Muenster, Domagkstr. 10, D-48149, Muenster, Germany.
  • Planz O; Interfaculty Institute for Cell Biology, Department of Immunology, University of Tuebingen, Auf der Morgenstelle 15, D-72076, Tuebingen, Germany.
  • Ludwig S; Institute of Virology Muenster (IVM), Westfaelische Wilhelms-University Muenster, Von-Esmarch-Str. 56, D-48149, Muenster, Germany.
  • Ehrhardt C; Institute of Virology Muenster (IVM), Westfaelische Wilhelms-University Muenster, Von-Esmarch-Str. 56, D-48149, Muenster, Germany. ehrhardc@uni-muenster.de.
Sci Rep ; 8(1): 9114, 2018 06 14.
Article em En | MEDLINE | ID: mdl-29904167
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Staphylococcus aureus / Benzamidas / MAP Quinase Quinase Quinases / Inibidores de Proteínas Quinases / Antibacterianos Limite: Animals / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Staphylococcus aureus / Benzamidas / MAP Quinase Quinase Quinases / Inibidores de Proteínas Quinases / Antibacterianos Limite: Animals / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha