Expression of Programmed Death-Ligand 1 by Human Colonic CD90<sup>+</sup> Stromal Cells Differs Between Ulcerative Colitis and Crohn's Disease and Determines Their Capacity to Suppress Th1 Cells.

Beswick, Ellen J; Grim, Carl; Singh, Abinav; Aguirre, Jose E; Tafoya, Marissa; Qiu, Suimin; Rogler, Gerhard; McKee, Rohini; Samedi, Von; Ma, Thomas Y; Reyes, Victor E; Powell, Don W; Pinchuk, Irina V

Expression of Programmed Death-Ligand 1 by Human Colonic CD90⁺ Stromal Cells Differs Between Ulcerative Colitis and Crohn's Disease and Determines Their Capacity to Suppress Th1 Cells.

Beswick, Ellen J; Grim, Carl; Singh, Abinav; Aguirre, Jose E; Tafoya, Marissa; Qiu, Suimin; Rogler, Gerhard; McKee, Rohini; Samedi, Von; Ma, Thomas Y; Reyes, Victor E; Powell, Don W; Pinchuk, Irina V.

Afiliação

Beswick EJ; Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM, United States.
Grim C; Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, United States.
Singh A; Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, United States.
Aguirre JE; Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, United States.
Tafoya M; Department of Pathology, University of New Mexico, Albuquerque, NM, United States.
Qiu S; Department of Pathology, University of Texas Medical Branch, Galveston, TX, United States.
Rogler G; Department of Gastroenterology and Hepatology, University Hospital of Zürich, Zürich, Switzerland.
McKee R; Department of Surgery, University of New Mexico, Albuquerque, NM, United States.
Samedi V; Department of Pathology, University of New Mexico, Albuquerque, NM, United States.
Ma TY; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of New Mexico, Albuquerque, NM, United States.
Reyes VE; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States.
Powell DW; Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, United States.
Pinchuk IV; Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, United States.

Front Immunol ; 9: 1125, 2018.

Article em En | MEDLINE | ID: mdl-29910803

Assuntos

Antígeno B7-H1/genética; Colite Ulcerativa/etiologia; Colite Ulcerativa/metabolismo; Doença de Crohn/etiologia; Doença de Crohn/metabolismo; Células Estromais/metabolismo; Células Th1/imunologia; Células Th1/metabolismo; Antígenos Thy-1/metabolismo; Actinas/metabolismo; Adolescente; Adulto; Animais; Biomarcadores; Linfócitos T CD4-Positivos/imunologia; Linfócitos T CD4-Positivos/metabolismo; Colite Ulcerativa/patologia; Colite Ulcerativa/terapia; Doença de Crohn/patologia; Doença de Crohn/terapia; Citocinas/metabolismo; Feminino; Regulação da Expressão Gênica; Humanos; Mucosa Intestinal/imunologia; Mucosa Intestinal/metabolismo; Ativação Linfocitária; Masculino; Camundongos; Microscopia Confocal; Pessoa de Meia-Idade; Miofibroblastos/metabolismo; RNA Mensageiro/genética; Adulto Jovem

Palavras-chave

Crohn's disease; PD-L2; Th1 cells; fibroblasts; inflammatory bowel diseases; myofibroblasts; programmed death-ligand 1; ulcerative colitis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Colite Ulcerativa / Doença de Crohn / Células Estromais / Células Th1 / Antígenos Thy-1 / Antígeno B7-H1 Limite: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Front Immunol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

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