Infection of the basal ganglia by a murine coronavirus.
Science
; 229(4716): 877-9, 1985 Aug 30.
Article
em En
| MEDLINE
| ID: mdl-2992088
ABSTRACT
The coronavirus, mouse hepatitis virus strain A59 (MHV-A59), causes mild encephalitis and chronic demyelination. Immunohistochemical techniques showed that MHV-A59-infected C57BL/6 mice contained dense deposits of viral antigen in the subthalamic nucleus and substantia nigra, with fewer signs of infection in other regions of the brain. The animals showed extra- and intracellular vacuolation, neuronal loss, and gliosis in the subthalamic-nigral region. Such localization is unprecedented among known viral encephalitides of humans and other species. This infection by a member of a viral class capable of causing both encephalitis and persistent infection in several species may be related to postencephalitic parkinsonism.
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Base de dados:
MEDLINE
Assunto principal:
Gânglios da Base
/
Substância Negra
/
Vírus da Hepatite Murina
/
Infecções por Coronaviridae
/
Diencéfalo
/
Encefalite
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1985
Tipo de documento:
Article