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NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study.
Kakuta, Yoichi; Kawai, Yosuke; Okamoto, Daisuke; Takagawa, Tetsuya; Ikeya, Kentaro; Sakuraba, Hirotake; Nishida, Atsushi; Nakagawa, Shoko; Miura, Miki; Toyonaga, Takahiko; Onodera, Kei; Shinozaki, Masaru; Ishiguro, Yoh; Mizuno, Shinta; Takahara, Masahiro; Yanai, Shunichi; Hokari, Ryota; Nakagawa, Tomoo; Araki, Hiroshi; Motoya, Satoshi; Naito, Takeo; Moroi, Rintaro; Shiga, Hisashi; Endo, Katsuya; Kobayashi, Taku; Naganuma, Makoto; Hiraoka, Sakiko; Matsumoto, Takayuki; Nakamura, Shiro; Nakase, Hiroshi; Hisamatsu, Tadakazu; Sasaki, Makoto; Hanai, Hiroyuki; Andoh, Akira; Nagasaki, Masao; Kinouchi, Yoshitaka; Shimosegawa, Tooru; Masamune, Atsushi; Suzuki, Yasuo.
Afiliação
  • Kakuta Y; Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, Sendai, 980-8574, Japan. ykakuta@med.tohoku.ac.jp.
  • Kawai Y; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Okamoto D; Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
  • Takagawa T; Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, Sendai, 980-8574, Japan.
  • Ikeya K; Division of Internal Medicine, Department of Inflammatory Bowel Disease, Hyogo College of Medicine, Nishinomiya, Japan.
  • Sakuraba H; Centre for Gastroenterology and Inflammatory Bowel Disease Research, Hamamatsu South Hospital, Hamamatsu, Japan.
  • Nishida A; Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
  • Nakagawa S; Department of Gastroenterology, Shiga University of Medical Science, Otsu, Japan.
  • Miura M; Division of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Japan.
  • Toyonaga T; The Third Department of Internal Medicine, Kyorin University School of Medicine, Mitaka, Japan.
  • Onodera K; Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.
  • Shinozaki M; Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan.
  • Ishiguro Y; Department of Surgery, IMSUT Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
  • Mizuno S; Department of Gastroenterology and Hematology, Hirosaki National Hospital, Hirosaki, Japan.
  • Takahara M; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
  • Yanai S; Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
  • Hokari R; Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka, Japan.
  • Nakagawa T; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan.
  • Araki H; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Motoya S; Division of Endscopy, Gifu University Hospital, Gifu, Japan.
  • Naito T; IBD Center, Sapporo-Kosei General Hospital, Sapporo, Japan.
  • Moroi R; Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, Sendai, 980-8574, Japan.
  • Shiga H; Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, Sendai, 980-8574, Japan.
  • Endo K; Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, Sendai, 980-8574, Japan.
  • Kobayashi T; Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, Sendai, 980-8574, Japan.
  • Naganuma M; Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.
  • Hiraoka S; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
  • Matsumoto T; Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
  • Nakamura S; Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka, Japan.
  • Nakase H; Division of Internal Medicine, Department of Inflammatory Bowel Disease, Hyogo College of Medicine, Nishinomiya, Japan.
  • Hisamatsu T; Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan.
  • Sasaki M; The Third Department of Internal Medicine, Kyorin University School of Medicine, Mitaka, Japan.
  • Hanai H; Division of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Japan.
  • Andoh A; Centre for Gastroenterology and Inflammatory Bowel Disease Research, Hamamatsu South Hospital, Hamamatsu, Japan.
  • Nagasaki M; Department of Gastroenterology, Shiga University of Medical Science, Otsu, Japan.
  • Kinouchi Y; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Shimosegawa T; Health Administration Center, Center for the Advancement of Higher Education, Tohoku University, Sendai, Japan.
  • Masamune A; Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, Sendai, 980-8574, Japan.
  • Suzuki Y; Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, Sendai, 980-8574, Japan.
J Gastroenterol ; 53(9): 1065-1078, 2018 Sep.
Article em En | MEDLINE | ID: mdl-29923122
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirofosfatases / Azatioprina / Doenças Inflamatórias Intestinais / Biomarcadores Farmacológicos / Imunossupressores / Mercaptopurina Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Asia Idioma: En Revista: J Gastroenterol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirofosfatases / Azatioprina / Doenças Inflamatórias Intestinais / Biomarcadores Farmacológicos / Imunossupressores / Mercaptopurina Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Asia Idioma: En Revista: J Gastroenterol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Japão