Guajadial inhibits NSCLC growth and migration following activation of the VEGF receptor-2.
Fitoterapia
; 129: 73-77, 2018 Sep.
Article
em En
| MEDLINE
| ID: mdl-29928966
ABSTRACT
Guajadial, one of natural dialdehyde meroterpenoids, demonstrated significant antineoplasmic activity. The present research was to investigate the inhibitory effects of guajadial by using two NSCLC cells (A549 and H1650) proliferation and migration. Western blotting was employed to explore the underlying mechanisms of VEGF receptor (VEGFR)2-mediated. This research indicated that guajadial not only inhibited endothelial cell proliferation and migration but also suppress tumor growth in human NSCLC xenograft mouse models. It is also suggested that guajadial inhibited A549 proliferation via blocking the Ras/MAPK pathway.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Terpenos
/
Carcinoma Pulmonar de Células não Pequenas
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Receptor 2 de Fatores de Crescimento do Endotélio Vascular
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Antineoplásicos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Fitoterapia
Ano de publicação:
2018
Tipo de documento:
Article