Your browser doesn't support javascript.
loading
Relationship of American Indian blood quantum with osteoporosis risk: a cross-sectional study of American Indian women in Oklahoma.
Smith, B J; Leyva, M J; Stephens, L D; Aston, C E; Hermann, J; Payton, M; Baker, M Z.
Afiliação
  • Smith BJ; Department of Nutritional Sciences, Oklahoma State University, 420 Human Sciences, Stillwater, OK, 74078, USA. bjsmith@okstate.edu.
  • Leyva MJ; Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
  • Stephens LD; Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
  • Aston CE; Department of Pediatrics CMRI Metabolic Research Program, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
  • Hermann J; Department of Nutritional Sciences, Oklahoma State University, 420 Human Sciences, Stillwater, OK, 74078, USA.
  • Payton M; Department of Statistics, College of Arts and Sciences, Oklahoma State University, Stillwater, OK, USA.
  • Baker MZ; Section of Endocrinology and Diabetes, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Osteoporos Int ; 29(10): 2251-2260, 2018 Oct.
Article em En | MEDLINE | ID: mdl-29943190
Information regarding the prevalence and risk of osteoporosis among American Indian (AI) women is limited. This study showed that with increasing AI blood quantum, the prevalence of osteoporosis at the hip based on BMD T-scores decreased and this appeared to be independent of other risk factors. INTRODUCTION: This study was designed to investigate the effects of AI blood quantum (BQ) on osteoporosis prevalence and risk in a cohort of AI women in Oklahoma. METHODS: Women (n = 301), aged 50 years and older, were recruited to participate in the Oklahoma American Indian Women's Osteoporosis Study. Baseline bone density, fracture history, bone biochemical markers, and potential risk factors were assessed. Participants were stratified by AI BQ into BQ1 ≤ 25%, BQ2 = 25-49%, BQ3 = 50-74%, and BQ4 = 75-100%. The effects of BQ on the prevalence and risk of osteoporosis were evaluated. RESULTS: Based on T-scores, one in approximately eight women in the study was osteoporotic at one or more sites. The prevalence of osteoporosis decreased (p < 0.05) with increasing BQ, especially at the hip, trochanteric, and intertrochanter regions. No differences in bone-specific alkaline phosphatase and C-telopeptide were observed across BQ that could account for the differences in bone density. 25-OH vitamin D decreased with increasing BQ, but mean for each BQ1-4 was > 40 ng/mL. Fracture history did not differ across BQ, and though 52% of the population consumed less than the RDA for calcium, no effect of BQ was observed. CONCLUSIONS: In this cohort of women who identified as AI, greater Indian BQ was associated with a decrease in the prevalence of osteoporosis.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Indígenas Norte-Americanos / Osteoporose Pós-Menopausa Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Middle aged País/Região como assunto: America do norte Idioma: En Revista: Osteoporos Int Assunto da revista: METABOLISMO / ORTOPEDIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Indígenas Norte-Americanos / Osteoporose Pós-Menopausa Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Middle aged País/Região como assunto: America do norte Idioma: En Revista: Osteoporos Int Assunto da revista: METABOLISMO / ORTOPEDIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos