Gradual Crossover from Subdiffusion to Normal Diffusion: A Many-Body Effect in Protein Surface Water.
Phys Rev Lett
; 120(24): 248101, 2018 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-29956983
ABSTRACT
Dynamics of hydration water is essential for the function of biomacromolecules. Previous studies have demonstrated that water molecules exhibit subdiffusion on the surface of biomacromolecules; yet the microscopic mechanism remains vague. Here, by performing neutron scattering, molecular dynamics simulations, and analytic modeling on hydrated perdeuterated protein powders, we found water molecules jump randomly between trapping sites on protein surfaces, whose waiting times obey a broad distribution, resulting in subdiffusion. Moreover, the subdiffusive exponent gradually increases with observation time towards normal diffusion due to a many-body volume-exclusion effect.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Água
/
Proteínas
Idioma:
En
Revista:
Phys Rev Lett
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
China