Apatinib, a selective VEGFR2 inhibitor, improves the delivery of chemotherapeutic agents to tumors by normalizing tumor vessels in LoVo colon cancer xenograft mice.

Zhou, Kai; Zhang, Jing-Wei; Wang, Qi-Zhi; Liu, Wen-Yue; Liu, Jia-Li; Yao, Lan; Cai, Ming-Min; Ni, Sui-Ying; Cai, Qing-Yun; Wang, Guang-Ji; Zhou, Fang

Zhou, Kai; Zhang, Jing-Wei; Wang, Qi-Zhi; Liu, Wen-Yue; Liu, Jia-Li; Yao, Lan; Cai, Ming-Min; Ni, Sui-Ying; Cai, Qing-Yun; Wang, Guang-Ji; Zhou, Fang.

Afiliação

Zhou K; Key laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
Zhang JW; Key laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
Wang QZ; Key laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
Liu WY; Key laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
Liu JL; Key laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
Yao L; Key laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
Cai MM; Key laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
Ni SY; Key laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
Cai QY; Key laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
Wang GJ; Key laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China. guangjiwang@hotmail.com.
Zhou F; Key laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China. zf1113@163.com.

Acta Pharmacol Sin ; 40(4): 556-562, 2019 Apr.

Article em En | MEDLINE | ID: mdl-29977004

Assuntos

Antineoplásicos/farmacologia; Neoplasias do Colo/tratamento farmacológico; Doxorrubicina/farmacologia; Sistemas de Liberação de Medicamentos; Piridinas/química; Administração Oral; Animais; Antineoplásicos/administração & dosagem; Antineoplásicos/química; Proliferação de Células/efeitos dos fármacos; Neoplasias do Colo/patologia; Doxorrubicina/administração & dosagem; Doxorrubicina/química; Injeção Intratimpânica; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Piridinas/administração & dosagem; Piridinas/farmacologia; Microambiente Tumoral/efeitos dos fármacos; Receptor 2 de Fatores de Crescimento do Endotélio Vascular/antagonistas & inibidores; Receptor 2 de Fatores de Crescimento do Endotélio Vascular/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

adriamycin; anti-angiogenesis; apatinib; colon cancer.; combined therapy; normalization window; tumor vessel

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Doxorrubicina / Sistemas de Liberação de Medicamentos / Neoplasias do Colo / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Acta Pharmacol Sin Assunto da revista: FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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