A high-sensitivity HPLC-ELSD method for HPMC-AS quantification and its application in elucidating the release mechanism of HPMC-AS based amorphous solid dispersions.

Wang, Shan; Liu, Chengyu; Chen, Yuejie; Zhang, Zhen; Zhu, Alan; Qian, Feng

Wang, Shan; Liu, Chengyu; Chen, Yuejie; Zhang, Zhen; Zhu, Alan; Qian, Feng.

Afiliação

Wang S; School of Pharmaceutical Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing, China.
Liu C; School of Pharmaceutical Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing, China.
Chen Y; School of Pharmaceutical Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing, China.
Zhang Z; Pharmaceutical Development and Manufacture Science, Janssen Research & Development, Johnson & Johnson, Shanghai, China.
Zhu A; Pharmaceutical Development and Manufacture Science, Janssen Research & Development, Johnson & Johnson, Shanghai, China. Electronic address: dzhu7@its.jnj.com.
Qian F; School of Pharmaceutical Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing, China. Electronic address: qianfeng@tsinghua.edu.

Eur J Pharm Sci ; 122: 303-310, 2018 Sep 15.

Article em En | MEDLINE | ID: mdl-30006181

Assuntos

Cromatografia Líquida de Alta Pressão/métodos; Metilcelulose/análogos & derivados; Dessecação; Liberação Controlada de Fármacos; Cinética; Metilcelulose/análise; Metilcelulose/química

Palavras-chave

Amorphous solid dispersion; HPLC-ELSD; HPMC-AS; Posaconazole; Release mechanism

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cromatografia Líquida de Alta Pressão / Metilcelulose Tipo de estudo: Diagnostic_studies Idioma: En Revista: Eur J Pharm Sci Assunto da revista: FARMACIA / FARMACOLOGIA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

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