Accelerating the reversal of inflammatory pain with NPD1 and its receptor GPR37.
J Clin Invest
; 128(8): 3246-3249, 2018 08 01.
Article
em En
| MEDLINE
| ID: mdl-30010628
ABSTRACT
Resolution of inflammation is a critical process that is facilitated by specialized proresolving mediators (SPMs). In this issue, Bang et al. show that the G protein-coupled receptor GPR37 is a receptor for one such SPM, neuroprotectin D1. They also show that GPR37 activation in macrophages enhances phagocytosis, shifts cytokine release toward an antiinflammatory profile, and thereby helps to reverse inflammatory pain.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fagocitose
/
Macrófagos
Limite:
Humans
Idioma:
En
Revista:
J Clin Invest
Ano de publicação:
2018
Tipo de documento:
Article