Cytonuclear integration and co-evolution.
Nat Rev Genet
; 19(10): 635-648, 2018 10.
Article
em En
| MEDLINE
| ID: mdl-30018367
ABSTRACT
The partitioning of genetic material between the nucleus and cytoplasmic (mitochondrial and plastid) genomes within eukaryotic cells necessitates coordinated integration between these genomic compartments, with important evolutionary and biomedical implications. Classic questions persist about the pervasive reduction of cytoplasmic genomes via a combination of gene loss, transfer and functional replacement - and yet why they are almost always retained in some minimal form. One striking consequence of cytonuclear integration is the existence of 'chimeric' enzyme complexes composed of subunits encoded in two different genomes. Advances in structural biology and comparative genomics are yielding important insights into the evolution of such complexes, including correlated sequence changes and recruitment of novel subunits. Thus, chimeric cytonuclear complexes provide a powerful window into the mechanisms of molecular co-evolution.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Núcleo Celular
/
Evolução Molecular
/
Citoplasma
/
Genoma Mitocondrial
/
Genomas de Plastídeos
Idioma:
En
Revista:
Nat Rev Genet
Assunto da revista:
GENETICA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos