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Suppression of insulin feedback enhances the efficacy of PI3K inhibitors.
Hopkins, Benjamin D; Pauli, Chantal; Du, Xing; Wang, Diana G; Li, Xiang; Wu, David; Amadiume, Solomon C; Goncalves, Marcus D; Hodakoski, Cindy; Lundquist, Mark R; Bareja, Rohan; Ma, Yan; Harris, Emily M; Sboner, Andrea; Beltran, Himisha; Rubin, Mark A; Mukherjee, Siddhartha; Cantley, Lewis C.
Afiliação
  • Hopkins BD; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
  • Pauli C; Institute of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.
  • Du X; Englander Institute for Precision Medicine, Weill Cornell Medicine-New York Presbyterian Hospital, New York, NY, USA.
  • Wang DG; Department of Medicine, Division of Hematology and Oncology, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA.
  • Li X; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
  • Wu D; Weill Cornell Medicine/Rockefeller University/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, USA.
  • Amadiume SC; Weill Cornell Graduate School of Medical Sciences, New York, NY, USA.
  • Goncalves MD; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
  • Hodakoski C; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
  • Lundquist MR; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
  • Bareja R; Division of Endocrinology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Ma Y; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
  • Harris EM; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
  • Sboner A; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
  • Beltran H; Englander Institute for Precision Medicine, Weill Cornell Medicine-New York Presbyterian Hospital, New York, NY, USA.
  • Rubin MA; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
  • Mukherjee S; Department of Medicine, Division of Hematology and Oncology, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA.
  • Cantley LC; Department of Medicine, Division of Hematology and Oncology, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA.
Nature ; 560(7719): 499-503, 2018 08.
Article em En | MEDLINE | ID: mdl-30051890
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Retroalimentação Fisiológica / Inibidores de Proteínas Quinases / Inibidores de Fosfoinositídeo-3 Quinase / Insulina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Nature Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Retroalimentação Fisiológica / Inibidores de Proteínas Quinases / Inibidores de Fosfoinositídeo-3 Quinase / Insulina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Nature Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos