The Dynamics and Optimal Control of a Hand-Foot-Mouth Disease Model.
Comput Math Methods Med
; 2018: 9254794, 2018.
Article
em En
| MEDLINE
| ID: mdl-30073033
ABSTRACT
We build and study the transmission dynamics of a hand-foot-mouth disease model with vaccination. The reproduction number is given, the existence of equilibria is obtained, and the global stability of disease-free equilibrium is proved by constructing the Lyapunov function. We also apply optimal control theory to the hand-foot-mouth disease model. The treatment and vaccination interventions are considered in the hand-foot-mouth disease model, and the optimal control strategies based on minimizing the cost of intervention and minimizing the number of the infected people are given. Numerical results show the usefulness of the optimization strategies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vacinação
/
Doença de Mão, Pé e Boca
/
Modelos Teóricos
Limite:
Humans
Idioma:
En
Revista:
Comput Math Methods Med
Assunto da revista:
INFORMATICA MEDICA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
China