Endoglin Targeting in Colorectal Tumor Microenvironment.

Becker, Lisa M; LeBleu, Valerie S

Becker, Lisa M; LeBleu, Valerie S.

Afiliação

Becker LM; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
LeBleu VS; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas. vlebleu@mdanderson.org.

Clin Cancer Res ; 24(24): 6110-6111, 2018 12 15.

Article em En | MEDLINE | ID: mdl-30076135

ABSTRACT

ABSTRACT

On endothelial cells, the TGFß/BMP-9 coreceptor, endoglin, emerged as a promising antiangiogenic target in colorectal cancer. Its promiscuous expression by cancer-associated fibroblasts (CAF) emerges to facilitate metastasis. The multitarget impact of neutralizing endoglin may offer added benefit in controlling colorectal cancer.See related article by Paauwe et al., p. 6331.

Assuntos

Fibroblastos Associados a Câncer; Neoplasias Colorretais; Antígenos CD; Endoglina; Células Endoteliais; Humanos; Receptores de Superfície Celular; Microambiente Tumoral

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Fibroblastos Associados a Câncer Limite: Humans Idioma: En Revista: Clin Cancer Res Assunto da revista: NEOPLASIAS Ano de publicação: 2018 Tipo de documento: Article

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