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Progress and perspectives in plant sterol and plant stanol research.
Jones, Peter J H; Shamloo, Maryam; MacKay, Dylan S; Rideout, Todd C; Myrie, Semone B; Plat, Jogchum; Roullet, Jean-Baptiste; Baer, David J; Calkins, Kara L; Davis, Harry R; Barton Duell, P; Ginsberg, Henry; Gylling, Helena; Jenkins, David; Lütjohann, Dieter; Moghadasian, Mohammad; Moreau, Robert A; Mymin, David; Ostlund, Richard E; Ras, Rouyanne T; Ochoa Reparaz, Javier; Trautwein, Elke A; Turley, Stephen; Vanmierlo, Tim; Weingärtner, Oliver.
Afiliação
  • Jones PJH; Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Manitoba, Canada.
  • Shamloo M; Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
  • MacKay DS; Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
  • Rideout TC; George and Fay Yee Centre for Healthcare Innovation, University of Manitoba, Winnipeg, Manitoba, Canada.
  • Myrie SB; George and Fay Yee Centre for Healthcare Innovation, University of Manitoba, Winnipeg, Manitoba, Canada.
  • Plat J; Department of Exercise and Nutrition Sciences, University of Buffalo, Buffalo, New York, USA.
  • Roullet JB; Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Manitoba, Canada.
  • Baer DJ; Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
  • Calkins KL; Department of Human Biology, Maastricht University, Maastricht, the Netherlands.
  • Davis HR; Division of Metabolism, Child Development and Rehabilitation Center-Portland, Department of Pediatrics, Oregon Health & Science University, Portland, Oregon, USA.
  • Barton Duell P; US Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Beltsville, Maryland, USA.
  • Ginsberg H; Department of Pediatrics, Division of Neonatology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA; and the UCLA Mattel's Children's Hospital, Los Angeles, California, USA.
  • Gylling H; CVPath Institute, Inc, Gaithersburg, Maryland, USA.
  • Jenkins D; Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, USA.
  • Lütjohann D; Institute of Human Nutrition, Columbia University Irving Medical Center, New York, New York, USA.
  • Moghadasian M; University of Helsinki and the Helsinki University Central Hospital, Helsinki, Finland.
  • Moreau RA; Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada; and the Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada.
  • Mymin D; Institute for Clinical Chemistry and Clinical Pharmacology, University of Bonn, Bonn, Germany.
  • Ostlund RE; Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
  • Ras RT; Eastern Regional Research Center, US Department of Agriculture, Agricultural Research Service, Wyndmoor, Pennsylvania, USA.
  • Ochoa Reparaz J; Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
  • Trautwein EA; Division of Endocrinology, Metabolism and Lipid Research, Washington University, St Louis, USA.
  • Turley S; Unilever Research & Development Vlaardingen, Vlaardingen, the Netherlands.
  • Vanmierlo T; Department of Biology, Eastern Washington University, Cheney, Washington, USA.
  • Weingärtner O; Unilever Research & Development Vlaardingen, Vlaardingen, the Netherlands.
Nutr Rev ; 76(10): 725-746, 2018 10 01.
Article em En | MEDLINE | ID: mdl-30101294
ABSTRACT
Current evidence indicates that foods with added plant sterols or stanols can lower serum levels of low-density lipoprotein cholesterol. This review summarizes the recent findings and deliberations of 31 experts in the field who participated in a scientific meeting in Winnipeg, Canada, on the health effects of plant sterols and stanols. Participants discussed issues including, but not limited to, the health benefits of plant sterols and stanols beyond cholesterol lowering, the role of plant sterols and stanols as adjuncts to diet and drugs, and the challenges involved in measuring plant sterols and stanols in biological samples. Variations in interindividual responses to plant sterols and stanols, as well as the personalization of lipid-lowering therapies, were addressed. Finally, the clinical aspects and treatment of sitosterolemia were reviewed. Although plant sterols and stanols continue to offer an efficacious and convenient dietary approach to cholesterol management, long-term clinical trials investigating the endpoints of cardiovascular disease are still lacking.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fitosteróis / Doenças Cardiovasculares / Dieta / Hipercolesterolemia / Enteropatias / Erros Inatos do Metabolismo Lipídico / Anticolesterolemiantes Limite: Humans País/Região como assunto: America do norte Idioma: En Revista: Nutr Rev Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fitosteróis / Doenças Cardiovasculares / Dieta / Hipercolesterolemia / Enteropatias / Erros Inatos do Metabolismo Lipídico / Anticolesterolemiantes Limite: Humans País/Região como assunto: America do norte Idioma: En Revista: Nutr Rev Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Canadá