Subcutaneous belimumab in the treatment of systemic lupus erythematosus.
Immunotherapy
; 10(13): 1163-1173, 2018 09.
Article
em En
| MEDLINE
| ID: mdl-30105936
ABSTRACT
Systemic lupus erythematosus is a chronic autoimmune disease with various clinical manifestations, organ involvement and laboratory findings. The disease can involve any organ including skin, joints, kidneys, central and peripheral nervous system, cardiovascular system and more. Currently, the cornerstone of treatment includes antimalarial and immunosuppressive medications and glucocorticosteroids. Recently, great effort has been invested in finding more targeted drugs for achieving better control of the disease with less adverse events. Intravenous belimumab was the first and only biologic drug to be approved by the US FDA and Health Canada for lupus over the last 50 years, and recently was studied in subcutaneous form. This paper will review the major belimumab trials with a focus on the subcutaneous form.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Fator Ativador de Células B
/
Anticorpos Monoclonais Humanizados
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Imunossupressores
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Imunoterapia
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Lúpus Eritematoso Sistêmico
Limite:
Humans
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Immunotherapy
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
TERAPEUTICA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Canadá