The transcription and expression profile of p53N236S mutant reveals new aspects of gain of function for mutant p53.
FEBS Lett
; 592(18): 3183-3197, 2018 09.
Article
em En
| MEDLINE
| ID: mdl-30107044
ABSTRACT
Missense mutations in the p53 coding gene cause loss and gain of function. We have identified a hotspot mutation, p53N236S , which results in the aggressive progression of tumorigenesis in a knock-in mouse model. To understand the biological significance of the p53N236S mutation, we performed ChIP-on-chip combined with microarray assay to profile the regulated gene expression pattern. We could classify the p53N236S mutant function into six categories. Among these, we reveal a new aspect of gain of function, the enhancement of wild-type p53 function, which has not been reported previously. We also show the existence of residual wild-type p53 function in p53N236S . Our data shed light on understanding the difference between this type of low-incidence hotspot p53 mutations and classical hotspot mutations.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
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Proteína Supressora de Tumor p53
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Transcriptoma
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Mutação com Ganho de Função
Limite:
Animals
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Humans
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
China