Oral tongue carcinoma among young patients: An analysis of risk factors and survival.
Oral Oncol
; 84: 7-11, 2018 09.
Article
em En
| MEDLINE
| ID: mdl-30115478
ABSTRACT
INTRODUCTION:
The incidence of oral tongue squamous cell carcinoma (OTSCC) in younger adults has rapidly increased over the past two decades. While tobacco and alcohol use may be less likely to cause these tumors, it remains controversial whether differences also exist in their prognosis. Our aim is to examine the risk factors for cancer among young (<45â¯years old) OTSCC patients at our institution, and to compare their recurrence and survival with older patients in a matched cohort. MATERIALS ANDMETHODS:
All OTSCC patients seen at our institution between 2000 and 2015 were reviewed. Patients under 45 who with sufficient treatment information were matched 11 on race, T-stage, and N-stage with patients 45 and older. Three-year recurrence and survival were determined in stratified and adjusted Cox regression models.RESULTS:
Of 397 OTSCC patients were seen at our institution, 117 (29%) were less than 45â¯years old. Younger patients were significantly more likely to be female, (50% vs. 39%; pâ¯=â¯0.04) and to abstain from tobacco (51% vs. 39%; pâ¯<â¯0.01). Young patients in the matched cohort were significantly more likely to have a recurrence (HR 3.9 95% CI 1.4-10.5). There was no difference in overall survival.CONCLUSION:
Younger OTSCC patients in a matched cohort were more likely to recur within 3â¯years, although there was no difference in overall mortality. Differences in risk factors and recurrence between older and younger patients suggest that some cancer among younger patients may be distinct from traditional OTSCC.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Língua
/
Carcinoma de Células Escamosas
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Oral Oncol
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2018
Tipo de documento:
Article