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Microsatellite variation of ESR1, ESR2, and AR in Serbian women with primary ovarian insufficiency.
Li, J; Dalgleish, R; Vujovic, S; Dragojevic-Dikic, S; Ivanisevic, M; Ivovic, M; Tancic, M; Thompson, J; Al-Azzawi, F.
Afiliação
  • Li J; a Gynaecology Research Unit , University Hospitals of Leicester , Leicester , UK.
  • Dalgleish R; b Department of Genetics and Genome Biology , University of Leicester , Leicester , UK.
  • Vujovic S; c Faculty of Medicine, Clinic of Endocrinology , University of Belgrade, Clinical Centre of Serbia , Belgrade , Serbia.
  • Dragojevic-Dikic S; c Faculty of Medicine, Clinic of Endocrinology , University of Belgrade, Clinical Centre of Serbia , Belgrade , Serbia.
  • Ivanisevic M; c Faculty of Medicine, Clinic of Endocrinology , University of Belgrade, Clinical Centre of Serbia , Belgrade , Serbia.
  • Ivovic M; c Faculty of Medicine, Clinic of Endocrinology , University of Belgrade, Clinical Centre of Serbia , Belgrade , Serbia.
  • Tancic M; c Faculty of Medicine, Clinic of Endocrinology , University of Belgrade, Clinical Centre of Serbia , Belgrade , Serbia.
  • Thompson J; d Department of Health Sciences , University of Leicester , Leicester , UK.
  • Al-Azzawi F; a Gynaecology Research Unit , University Hospitals of Leicester , Leicester , UK.
Climacteric ; 21(5): 472-477, 2018 10.
Article em En | MEDLINE | ID: mdl-30156935
OBJECTIVE: This study aimed to investigate the potential role of microsatellite polymorphisms of the estrogen receptor alpha gene (ESR1) TA repeat, estrogen receptor beta gene (ESR2) CA repeat, and androgen receptor gene (AR) CAG and GGN repeats among Serbian women with primary ovarian insufficiency (POI). These microsatellites have been reported to be associated with POI in different racial/ethnic populations. METHODS: A cohort of 196 POI cases matched with 544 fertile controls was recruited by the Institute for Endocrinology, Diabetes and Metabolic Disorders of Serbia between 2007 and 2010. DNA was extracted from saliva. The four microsatellites were genotyped using a PCR-based assay to determine the repeat lengths. RESULTS: POI patients carried shorter repeat lengths of ESR2 (CA)n than controls (P = 0.034), but the difference was small. ESR1 (TA)n was on the borderline of statistical differences between groups (P = 0.059). AR (CAG)n and (GGN)n showed no association with POI. CONCLUSIONS: We cautiously conclude that microsatellite polymorphisms of gonadal steroid receptor genes might contribute to the genetic basis of POI in Serbian women, but a larger-scale study and family-based studies are warranted to validate our findings even though the sample size in this study is larger than any previously published in this field.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Androgênicos / Insuficiência Ovariana Primária / Repetições de Microssatélites / Receptor alfa de Estrogênio / Receptor beta de Estrogênio Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans País/Região como assunto: Europa Idioma: En Revista: Climacteric Assunto da revista: GINECOLOGIA Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Androgênicos / Insuficiência Ovariana Primária / Repetições de Microssatélites / Receptor alfa de Estrogênio / Receptor beta de Estrogênio Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans País/Região como assunto: Europa Idioma: En Revista: Climacteric Assunto da revista: GINECOLOGIA Ano de publicação: 2018 Tipo de documento: Article