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Diabetes mellitus and hyperglycemia control on the risk of colorectal adenomatous polyps: a retrospective cohort study.
Budzynska, Katarzyna; Passerman, Daniel; White-Perkins, Denise; Rees, Della A; Xu, Jinping; Lamerato, Lois; Schooley, Susan.
Afiliação
  • Budzynska K; Department of Family Medicine, Henry Ford Hospital, Detroit, MI, USA. kbudzyn1@hfhs.org.
  • Passerman D; Department of Family Medicine, Henry Ford Health System, 3370 E Jefferson, Detroit, MI, 48207, USA. kbudzyn1@hfhs.org.
  • White-Perkins D; Department of Family Medicine, Henry Ford Hospital, Detroit, MI, USA.
  • Rees DA; Department of Family Medicine, Henry Ford Hospital, Detroit, MI, USA.
  • Xu J; Department of Family Medicine, Henry Ford Hospital, Detroit, MI, USA.
  • Lamerato L; Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, MI, USA.
  • Schooley S; Department of Family Medicine, Henry Ford Hospital, Detroit, MI, USA.
BMC Fam Pract ; 19(1): 145, 2018 08 29.
Article em En | MEDLINE | ID: mdl-30157768
ABSTRACT

BACKGROUND:

Colorectal cancer (CRC) develops from colorectal adenomatous polyps. This study is to determine if diabetes mellitus (DM), its treatment, and hemoglobin A1c (HbA1c) level are associated with increased risk of colorectal adenomatous polyps.

METHODS:

This was a retrospective cohort study that included patients who had at least one colonoscopy and were continuously enrolled in a single managed care organization during a 10-year period (2002-2012). Of these patients (N = 11,933), 1800 were randomly selected for chart review to examine the details of colonoscopy and pathology findings and to confirm the diagnosis of DM. Multivariable logistic regression analyses were performed to assess the associations between DM, its treatment, HbA1c level and adenomatous polyps (our main outcome).

RESULTS:

Among the total of 11,933 patients with a mean (standard deviation) age of 56 (± 8.8) years, 2306 (19.3%) had DM and 75 (0.6%) had CRC. Among the 1800 under chart review, 445 (24.7%) had DM, 11 (0.6%) had CRC and 537 (29.8%) had adenomatous polyps. In bivariate analysis, patients with DM had 1.45 odds of developing adenomatous polyps compared to those without DM. This effect was attenuated (odds ratio = 1.25, 95% CI 0.96-1.62, p = 0.09) after adjusting for confounders such as age, gender, race/ethnicity, and body mass index. There was no significant association between type or duration of DM treatment or HbA1c level and adenomatous polyps.

CONCLUSIONS:

Our study confirmed the known increased risk of adenomatous polyps with advancing age, male gender, Hispanic race/ethnicity and higher body mass index. Although it suggested an association between DM and adenomatous polyps, a statistically significant association was not observed after controlling for other potential confounders. Further studies with a larger sample size are needed to further elucidate this relationship.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Pólipos do Colo / Pólipos Adenomatosos / Diabetes Mellitus Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: America do norte Idioma: En Revista: BMC Fam Pract Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Pólipos do Colo / Pólipos Adenomatosos / Diabetes Mellitus Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: America do norte Idioma: En Revista: BMC Fam Pract Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos