Intracranial Transplantation of Pancreatic Islets Attenuates Cognitive and Peripheral Metabolic Dysfunctions in a Rat Model of Sporadic Alzheimer's Disease.

Bloch, Konstantin; Gil-Ad, Irit; Vanichkin, Alexey; Hornfeld, Shay Henry; Taler, Michal; Dar, Shira; Azarov, Dmitry; Vardi, Pnina; Weizman, Abraham

Bloch, Konstantin; Gil-Ad, Irit; Vanichkin, Alexey; Hornfeld, Shay Henry; Taler, Michal; Dar, Shira; Azarov, Dmitry; Vardi, Pnina; Weizman, Abraham.

Afiliação

Bloch K; Laboratory of Diabetes and Obesity Research, Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel.
Gil-Ad I; Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel.
Vanichkin A; Laboratory of Transplantation, Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel.
Hornfeld SH; Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel.
Taler M; Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel.
Dar S; Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel.
Azarov D; Laboratory of Diabetes and Obesity Research, Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel.
Vardi P; Laboratory of Diabetes and Obesity Research, Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel.
Weizman A; Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel.

J Alzheimers Dis ; 65(4): 1445-1458, 2018.

Article em En | MEDLINE | ID: mdl-30175977

Assuntos

Doença de Alzheimer/complicações; Transtornos Cognitivos/etiologia; Transtornos Cognitivos/cirurgia; Doenças Metabólicas/etiologia; Doenças Metabólicas/cirurgia; Doença de Alzheimer/induzido quimicamente; Animais; Glicemia/efeitos dos fármacos; Glicemia/metabolismo; Peso Corporal; Encéfalo/metabolismo; Encéfalo/patologia; Modelos Animais de Doenças; Ingestão de Líquidos/efeitos dos fármacos; Ingestão de Líquidos/fisiologia; Ingestão de Alimentos/efeitos dos fármacos; Seguimentos; Transplante das Ilhotas Pancreáticas; Masculino; Metabolismo/fisiologia; Pâncreas/patologia; Ratos; Ratos Endogâmicos Lew; Ratos Wistar; Estreptozocina

Palavras-chave

Alzheimer's disease; animal models; dementia; obesity; pancreatic islet transplantation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos Cognitivos / Doença de Alzheimer / Doenças Metabólicas Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: J Alzheimers Dis Assunto da revista: GERIATRIA / NEUROLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Israel

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