Long-term favorable cardiovascular risk profile and 39-year development of major and minor electrocardiographic abnormalities - The Chicago Healthy Aging Study (CHAS).
J Electrocardiol
; 51(5): 863-869, 2018.
Article
em En
| MEDLINE
| ID: mdl-30177330
ABSTRACT
BACKGROUND:
Data are limited on long-term associations of favorable cardiovascular risk profile (i.e., low-risk) and changes in risk profile with ECG abnormality development.METHODS:
The Chicago Healthy Aging Study (CHAS) involved re-examination of 1395 participants, ages 65-84â¯years in 2007-10, free of baseline major ECG abnormalities or MI in 1967-1973. Stratified sampling method was used to recruit participants based on their baseline risk profile (low-risk and not low-risk). Low-risk status was defined as untreated SBP/DBPâ¯≤â¯120/≤80â¯mmâ¯Hg, untreated total cholesterol <200â¯mg/dl, not smoking, BMI <25â¯kg/m2, and no diabetes. ECG abnormalities were defined by Minnesota code criteria. Multinomial logistic regression was used.RESULTS:
There were 28% women, 9% blacks, and 20% with baseline low-risk status. At follow-up, 21% developed ≥1 major ECG abnormalities, and 58% developed ≥1 minor ECG abnormalities. With multivariable adjustment, compared to those with 2â¯+â¯high-risk factors, odds for developing from normal to any major ECG abnormalities were lower by 57%, 49%, and 35%, respectively, in persons with low-risk, any moderate-risk, and 1 high-risk factor (P-trendâ¯=â¯0.002). Findings were similar for some common specific subtypes of major and minor abnormalities. Associations were mainly due to baseline smoking and BMI. Remaining free of high-risk factors, or improving risk profile over time was also associated with lower major ECG abnormality development by 70% vs. always having any high-risk factor.CONCLUSIONS:
Favorable CVD risk profile earlier in life and maintenance or improvement in risk profile over time are associated with lower risk of ECG abnormality development at older age.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
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Fatores de Risco
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Eletrocardiografia
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Envelhecimento Saudável
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Electrocardiol
Ano de publicação:
2018
Tipo de documento:
Article