Synthesis and Biological Evaluation of Fentanyl Analogues Modified at Phenyl Groups with Alkyls.

Qin, Yajuan; Ni, Luofan; Shi, Jiawei; Zhu, Zhiying; Shi, Saijian; Lam, Ai-Leen; Magiera, Julia; Sekar, Sunderajhan; Kuo, Andy; Smith, Maree T; Li, Tingyou

Qin, Yajuan; Ni, Luofan; Shi, Jiawei; Zhu, Zhiying; Shi, Saijian; Lam, Ai-Leen; Magiera, Julia; Sekar, Sunderajhan; Kuo, Andy; Smith, Maree T; Li, Tingyou.

Afiliação

Qin Y; School of Pharmacy , Nanjing Medical University , Nanjing 211166 , China.
Ni L; School of Pharmacy , Nanjing Medical University , Nanjing 211166 , China.
Shi J; School of Pharmacy , Nanjing Medical University , Nanjing 211166 , China.
Zhu Z; School of Pharmacy , Nanjing Medical University , Nanjing 211166 , China.
Shi S; School of Pharmacy , Nanjing Medical University , Nanjing 211166 , China.
Lam AL; School of Biomedical Sciences, Faculty of Medicine , The University of Queensland , Brisbane , QLD 4072 , Australia.
Magiera J; School of Biomedical Sciences, Faculty of Medicine , The University of Queensland , Brisbane , QLD 4072 , Australia.
Sekar S; School of Biomedical Sciences, Faculty of Medicine , The University of Queensland , Brisbane , QLD 4072 , Australia.
Kuo A; School of Biomedical Sciences, Faculty of Medicine , The University of Queensland , Brisbane , QLD 4072 , Australia.
Smith MT; School of Biomedical Sciences, Faculty of Medicine , The University of Queensland , Brisbane , QLD 4072 , Australia.
Li T; School of Pharmacy , Nanjing Medical University , Nanjing 211166 , China.

ACS Chem Neurosci ; 10(1): 201-208, 2019 01 16.

Article em En | MEDLINE | ID: mdl-30179508

Assuntos

Analgésicos Opioides/metabolismo; Fentanila/análogos & derivados; Fentanila/metabolismo; Receptores Opioides/metabolismo; Analgésicos Opioides/síntese química; Relação Dose-Resposta a Droga; Avaliação Pré-Clínica de Medicamentos/métodos; Ala(2)-MePhe(4)-Gly(5)-Encefalina/análogos & derivados; Ala(2)-MePhe(4)-Gly(5)-Encefalina/síntese química; Ala(2)-MePhe(4)-Gly(5)-Encefalina/metabolismo; Fentanila/síntese química; Células HEK293; Humanos; Antagonistas de Entorpecentes/síntese química; Antagonistas de Entorpecentes/metabolismo; Ligação Proteica/fisiologia

Palavras-chave

Fentanyl; analgesics; opioid; ß-arrestin2

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fentanila / Receptores Opioides / Analgésicos Opioides Limite: Humans Idioma: En Revista: ACS Chem Neurosci Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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