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The effects of combined oxytocin and cognitive behavioral social skills training on social cognition in schizophrenia.
Strauss, Gregory P; Granholm, Eric; Holden, Jason L; Ruiz, Ivan; Gold, James M; Kelly, Deanna L; Buchanan, Robert W.
Afiliação
  • Strauss GP; Department of Psychology,University of Georgia,Athens, GA,USA.
  • Granholm E; VA San Diego Healthcare System, Department of Psychiatry,University of California San Diego School of Medicine,San Diego, CA,USA.
  • Holden JL; VA San Diego Healthcare System, Department of Psychiatry,University of California San Diego School of Medicine,San Diego, CA,USA.
  • Ruiz I; Department of Psychology,University of Georgia,Athens, GA,USA.
  • Gold JM; Department of Psychiatry,Maryland Psychiatric Research Center, University of Maryland School of Medicine,Baltimore, MD,USA.
  • Kelly DL; Department of Psychiatry,Maryland Psychiatric Research Center, University of Maryland School of Medicine,Baltimore, MD,USA.
  • Buchanan RW; Department of Psychiatry,Maryland Psychiatric Research Center, University of Maryland School of Medicine,Baltimore, MD,USA.
Psychol Med ; 49(10): 1731-1739, 2019 07.
Article em En | MEDLINE | ID: mdl-30180918
ABSTRACT

BACKGROUND:

Individuals with schizophrenia have deficits in social cognition that are associated with poor functional outcome. Unfortunately, current treatments result in only modest improvement in social cognition. Oxytocin, a neuropeptide with pro-social effects, has significant benefits for social cognition in the general population. However, studies examining the efficacy of oxytocin in schizophrenia have yielded inconsistent results. One reason for inconsistency may be that oxytocin has typically not been combined with psychosocial interventions. It may be necessary for individuals with schizophrenia to receive concurrent psychosocial treatment while taking oxytocin to have the context needed to make gains in social cognitive skills.

METHODS:

The current study tested this hypothesis in a 24-week (48 session) double-blind, placebo-controlled trial that combined oxytocin and Cognitive-Behavioral Social Skills Training (CBSST), which included elements from Social Cognition and Interaction Training (SCIT). Participants included 62 outpatients diagnosed with schizophrenia (placebo n = 31; oxytocin n = 31) who received 36 IU BID, with supervised administration 45 min prior to sessions on CBSST group therapy days. Participants completed a battery of measures administered at 0, 12, and 24 weeks that assessed social cognition.

RESULTS:

CBSST generally failed to enhance social cognition from baseline to end of study, and there was no additive benefit of oxytocin beyond the effects of CBSST alone.

CONCLUSIONS:

Findings suggest that combined CBSST and oxytocin had minimal benefit for social cognition, adding to the growing literature indicating null effects of oxytocin in multi-dose trials. Methodological and biological factors may contribute to inconsistent results across studies.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esquizofrenia / Percepção Social / Ocitocina / Terapia Cognitivo-Comportamental / Habilidades Sociais / Relações Interpessoais Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Psychol Med Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esquizofrenia / Percepção Social / Ocitocina / Terapia Cognitivo-Comportamental / Habilidades Sociais / Relações Interpessoais Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Psychol Med Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos