Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin.

Fuqua, Brie K; Lu, Yan; Frazer, David M; Darshan, Deepak; Wilkins, Sarah J; Dunn, Linda; Loguinov, Alex V; Kogan, Scott C; Matak, Pavle; Chen, Huijun; Dunaief, Joshua L; Vulpe, Chris D; Anderson, Gregory J

Fuqua, Brie K; Lu, Yan; Frazer, David M; Darshan, Deepak; Wilkins, Sarah J; Dunn, Linda; Loguinov, Alex V; Kogan, Scott C; Matak, Pavle; Chen, Huijun; Dunaief, Joshua L; Vulpe, Chris D; Anderson, Gregory J.

Afiliação

Fuqua BK; Department of Nutritional Science and Toxicology, University of California, Berkeley, Berkeley, California.
Lu Y; Iron Metabolism Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Frazer DM; Iron Metabolism Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Darshan D; Iron Metabolism Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Wilkins SJ; Iron Metabolism Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Dunn L; Iron Metabolism Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Loguinov AV; Iron Metabolism Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Kogan SC; Department of Nutritional Science and Toxicology, University of California, Berkeley, Berkeley, California.
Matak P; Department of Laboratory Medicine and Helen Diller Comprehensive Cancer Center and Mouse Pathology Core, University of California, San Francisco, California.
Chen H; Department of Pharmacology and Cancer Biology, Duke University, Duke University Medical Center, Durham, North Carolina.
Dunaief JL; Medical School, Nanjing University, Nanjing, Jiangsu Province, China.
Vulpe CD; FM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania.
Anderson GJ; Department of Nutritional Science and Toxicology, University of California, Berkeley, Berkeley, California.

Cell Mol Gastroenterol Hepatol ; 6(4): 405-427, 2018.

Article em En | MEDLINE | ID: mdl-30182051

Assuntos

Ceruloplasmina/deficiência; Ferro/metabolismo; Proteínas de Membrana/deficiência; Absorção Fisiológica; Anemia/patologia; Animais; Animais Lactentes; Tamanho Corporal; Peso Corporal; Proteínas de Transporte de Cátions/metabolismo; Ceruloplasmina/metabolismo; Modelos Animais de Doenças; Duodeno/metabolismo; Enterócitos/metabolismo; Feminino; Ligadura; Masculino; Proteínas de Membrana/metabolismo; Camundongos Endogâmicos C57BL; Camundongos Knockout; Especificidade de Órgãos; Fenótipo

Palavras-chave

CP, ceruloplasmin; Cp-/-, mice lacking CP in the whole body; DAB, 3,3'-diaminobenzidine; FDR, false discovery rate; FPN1, ferroportin 1; GI, gastrointestinal; HCI, hydrochloric acid; HEPH, hephaestin; Heph-/-, mice lacking HEPH in the whole body; Heph-/-Cp-/- or DKO, double-knockout mice lacking both HEPH and CP; Hephfl/fl, mice with floxed Heph alleles; Hephfl/flCp-/-, mice with floxed Heph alleles and lacking CP in the whole body; Hephint/int, mice lacking HEPH in the intestine alone; Hephint/intCp-/-, mice lacking HEPH in the intestine alone and lacking CP in the whole body; Hephsla/slaCp-/-, mice lacking CP in the whole body and expressing only the sla mutant form of HEPH; Intestinal Iron Absorption; Iron Deficiency Anemia; Iron Overload; MCF, multicopper ferroxidase; NTBI, non-transferrin bound iron; Non-Transferrin Bound Iron; PBS, phosphate-buffered saline; PCR, polymerase chain reaction; SD, standard deviation; TBST, Tris-buffered saline with 0.1% Tween-20; TF, transferrin; TIBC, total iron binding capacity; WT, wild-type; sla, sex-linked anemia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ceruloplasmina / Ferro / Proteínas de Membrana Limite: Animals Idioma: En Revista: Cell Mol Gastroenterol Hepatol Ano de publicação: 2018 Tipo de documento: Article

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