Neonatal urticaria: Could it be CAPS?
Pediatr Dermatol
; 35(6): e420-e421, 2018 Nov.
Article
em En
| MEDLINE
| ID: mdl-30187963
A neonatal boy presented with a persistent urticarial rash. Initial investigations showed raised inflammatory markers and evidence of systemic inflammation. A working diagnosis of cryopyrin-associated periodic syndrome (CAPS) was made, and the patient responded extremely well to Anakinra. Molecular genetic testing revealed a somatic mutation (affecting 12.5% of cells) in the NLRP3 gene, accounting for the persistent inflammatory state but milder phenotype as seen in our patient.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Urticária
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Antirreumáticos
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Proteína Antagonista do Receptor de Interleucina 1
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Síndromes Periódicas Associadas à Criopirina
Limite:
Humans
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Male
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Newborn
Idioma:
En
Revista:
Pediatr Dermatol
Ano de publicação:
2018
Tipo de documento:
Article