Biology and treatment of BRAF mutant metastatic melanoma.
Melanoma Manag
; 3(1): 33-45, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-30190871
ABSTRACT
BRAF inhibitors were among the first systemic therapies to show clinical benefit in metastatic melanoma. Here, we review the spectrum of BRAF mutations in melanoma, their role in oncogenesis, clinicopathological associations and response to treatment. The differing biology and clinical features of V600E- and V600K-mutated melanoma are outlined. The molecular changes associated with BRAF fusion genes and their response to targeted therapies, as well as the role of immunotherapy in treatment sequencing with targeted therapies are discussed.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Melanoma Manag
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Austrália